Boramino acid as a marker for amino acid transporters
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چکیده
منابع مشابه
Boramino acid as a marker for amino acid transporters.
Amino acid transporters (AATs) are a series of integral channels for uphill cellular uptake of nutrients and neurotransmitters. Abnormal expression of AATs is often associated with cancer, addiction, and multiple mental diseases. Although methods to evaluate in vivo expression of AATs would be highly useful, efforts to develop them have been hampered by a lack of appropriate tracers. We describ...
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• The heavy subunits (molecular mass of ~90 and ~80 kDa for rBAT and 4F2hc, respectively) are type II membrane N-glycoproteins with a single transmembrane domain, an intracellular NH2 terminus, and an extracellular COOH terminus significantly homologous to insect and bacterial glucosidases (FIGURE 1). Recently, X-ray diffraction of the extracellular domain of human 4F2hc revealed a three-dimens...
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ژورنال
عنوان ژورنال: Science Advances
سال: 2015
ISSN: 2375-2548
DOI: 10.1126/sciadv.1500694